Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APPPS1 Mice
المؤلفون المشاركون
Tan, Ya-Xin
Liu, Guang-Cai
Chen, Hong-Lan
Lu, Min-Nan
Chen, Bo
Hu, Tao
Zhang, Li
Mao, Rui
Li, Shan
Mei, Rong
Wang, Xu-Yang
Xiyang, Yan-Bin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-18
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer’s disease (AD).
Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition.
Physical exercise has been shown to be an effective cognitive enhancer that reduces the risk of AD in elderly individuals, but the underlying mechanisms are far from being fully understood.
We explored whether long-term treadmill exercise attenuates amyloid precursor protein (APP)/presenilin-1 (PS1) mutation-induced aberrant network activity and thus improves cognition by altering the numbers and/or distribution of voltage-gated sodium channels (Nav) in transgenic mice.
APP/PS1 mice aged 2, 3.5, 5, 6.5, 8, and 9 months underwent treadmill exercise with different durations or at different stages of AD.
The alterations in memory, electroencephalogram (EEG) recordings, and expression levels and distributions of Nav functional members (Nav1.1α, Nav1.2, Nav1.6, and Navβ2) were evaluated.
The results revealed that treadmill exercise with 12- and 24-week durations 1) induced significant improvement in novel object recognition (NOR) memory and Morris water maze (MWM) spatial memory; 2) partially reduced abnormal spike activity; and 3) redressed the disturbed cellular distribution of Nav1.1α, aberrant Navβ2 cleavage augmentation, and Nav1.6 upregulation.
Additionally, APP/PS1 mice in the 24-week exercise group showed better performance in the NOR task and a large decrease in Nav1.6 expression, which was close to the wild-type level.
This study suggests that exercise improves cognition and neural activity by altering the numbers and distribution of hippocampal Nav in APP/PS1 mice.
Long-term treadmill exercise, for about 24 weeks, starting in the preclinical stage, is a promising therapeutic strategy for preventing AD and halting its progress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Ya-Xin& Liu, Guang-Cai& Chen, Hong-Lan& Lu, Min-Nan& Chen, Bo& Hu, Tao…[et al.]. 2020. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APPPS1 Mice. Neural Plasticity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1203177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Ya-Xin…[et al.]. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APPPS1 Mice. Neural Plasticity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1203177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Ya-Xin& Liu, Guang-Cai& Chen, Hong-Lan& Lu, Min-Nan& Chen, Bo& Hu, Tao…[et al.]. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APPPS1 Mice. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1203177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر