Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation
المؤلفون المشاركون
Duan, Ran
Liu, Ziqi
Yuan, Li
He, Shihao
Xu, Zongsheng
Xiao, Chu
Yi, Zhe
Wang, Rong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Asymptomatic carotid artery stenosis (CAS) and occlusion (CAO) disrupt cerebral hemodynamics.
There are few studies on the brain network changes and compensation associated with the progression from chronic CAS to CAO.
In the current study, our goal is to improve the understanding of the specific abnormalities and compensatory phenomena associated with the functional connection in patients with CAS and CAO.
In this prospective study, 27 patients with CAO, 29 patients with CAS, and 15 healthy controls matched for age, sex, education, handedness, and risk factors underwent neuropsychological testing and resting-state functional magnetic resonance (rs-fMRI) imaging simultaneously; graph theoretical analysis of brain networks was performed to determine the relationship between changes in brain network connectivity and the progression from internal CAS to CAO.
The global properties of the brain network assortativity (p=0.002), hierarchy (p=0.002), network efficiency (p=0.011), and small-worldness (p=0.009) were significantly more abnormal in the CAS group than in the control and CAO groups.
In patients with CAS and CAO, the nodal efficiency of key nodes in multiple brain regions decreased, while the affected hemisphere lost many key functional connections.
In this study, we found that patients with CAS showed grade reconstruction, invalid connections, and other phenomena that impaired the efficiency of information transmission in the brain network.
A compensatory functional connection in the contralateral cerebral hemisphere of patients with CAS and CAO may be an important mechanism that maintains clinical asymptomatic performance.
This study not only reveals the compensation mechanism of cerebral hemisphere ischemia but also validates previous explanations for brain function connectivity, which can help provide interventions in advance and reduce the impairment of higher brain functions.
This trial is registered with Clinical Trial Registration-URL http://www.chictr.org.cn and Unique identifier ChiCTR1900023610.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Shihao& Liu, Ziqi& Xu, Zongsheng& Duan, Ran& Yuan, Li& Xiao, Chu…[et al.]. 2020. Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Shihao…[et al.]. Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1203182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Shihao& Liu, Ziqi& Xu, Zongsheng& Duan, Ran& Yuan, Li& Xiao, Chu…[et al.]. Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر