Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat
المؤلفون المشاركون
Chen, Penghui
Hou, Shule
Chen, Jiarui
Chen, Junmin
Sun, Lianhua
Chen, Jianyong
He, Baihui
Li, Yue
Qin, Huan
Hong, Yuren
Li, Shuna
He, Jingchun
Gao, Dekun
Mammano, Fabio
Yang, Jun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Autophagy and apoptosis have a complex interplay in the early embryo development.
The development of spiral ganglion neurons (SGNs) in addition to Corti’s organ in the mammalian cochlea remains crucial in the first two-week postnatal period.
To investigate the roles of apoptosis and autophagy in the development of SGNs, light microscopy was used to observe the morphological changes of SGNs.
The number of SGNs was decreased from P1 to P7 and plateaued from P10 to P14.
Immunohistochemistry results revealed positive expression of cleaved-caspase3, bcl-2, microtubule-associated protein light chain 3-II (LC3-II), Beclin1, and sequestosome 1 (SQSTM1/P62) in SGNs.
The apoptotic bodies and autophagosomes and autolysosomes were also identified by transmission electron microscopy at P1 and P7.
Real-time PCR and western blotting results revealed that the apoptotic activity peaked at P7 and the autophagy activity was gradually upregulated along with the development.
Taken together, our results for the first time showed that autophagy and apoptosis in SGNs play distinct roles during specific developmental phases in a time-dependent manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hou, Shule& Chen, Penghui& Chen, Jiarui& Chen, Junmin& Sun, Lianhua& Chen, Jianyong…[et al.]. 2020. Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat. Neural Plasticity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hou, Shule…[et al.]. Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat. Neural Plasticity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1203188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hou, Shule& Chen, Penghui& Chen, Jiarui& Chen, Junmin& Sun, Lianhua& Chen, Jianyong…[et al.]. Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر