Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac Surgery
المؤلفون المشاركون
Zheng, Xiaodong
Zhang, Xuelin
Jiang, Zhaoshun
Zhang, Xixue
Lv, Yating
Zhang, Huibiao
Jiang, Chongyi
Lin, Guangwu
Gu, Weidong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
Recently, it has been demonstrated that patients with subtle preexisting cognitive impairment were susceptible to delayed neurocognitive recovery (DNR).
This present study investigated whether preoperative alterations in gray matter volume, spontaneous activity, or functional connectivity (FC) were associated with DNR.
Methods.
This was a nested case-control study of older adults (≥60 years) undergoing noncardiac surgery.
All patients received MRI scan at least 1 day prior to surgery.
Cognitive function was assessed prior to surgery and at 7-14 days postsurgery.
Preoperative gray matter volume, amplitude of low-frequency fluctuation (ALFF), and FC were compared between the DNR patients and non-DNR patients.
The independent risk factors associated with DNR were identified using a multivariate logistic regression model.
Results.
Of the 74 patients who completed assessments, 16/74 (21.6%) had DNR following surgery.
There were no differences in gray matter volume between the two groups.
However, the DNR patients exhibited higher preoperative ALFF in the bilateral middle cingulate cortex (MCC) and left fusiform gyrus and lower preoperative FC between the bilateral MCC and left calcarine than the non-DNR patients.
The multivariate logistic regression analysis showed that higher preoperative spontaneous activity in the bilateral MCC was independently associated with a higher risk of DNR (OR=3.11, 95% CI, 1.30-7.45; P=0.011).
A longer education duration (OR=0.57, 95% CI, 0.41-0.81; P=0.001) and higher preoperative FC between the bilateral MCC and left calcarine (OR=0.40, 95% CI, 0.18-0.92; P=0.031) were independently correlated with a lower risk of DNR.
Conclusions.
Preoperative higher ALFF in the bilateral MCC and lower FC between the bilateral MCC and left calcarine were independently associated with the occurrence of DNR.
The present fMRI study identified possible preoperative neuroimaging risk factors for DNR.
This trial is registered with Chinese Clinical Trial Registry ChiCTR-DCD-15006096.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Zhaoshun& Zhang, Xixue& Lv, Yating& Zheng, Xiaodong& Zhang, Huibiao& Zhang, Xuelin…[et al.]. 2020. Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac Surgery. Neural Plasticity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203200
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Zhaoshun…[et al.]. Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac Surgery. Neural Plasticity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203200
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Zhaoshun& Zhang, Xixue& Lv, Yating& Zheng, Xiaodong& Zhang, Huibiao& Zhang, Xuelin…[et al.]. Preoperative Altered Spontaneous Brain Activity and Functional Connectivity Were Independent Risk Factors for Delayed Neurocognitive Recovery in Older Adults Undergoing Noncardiac Surgery. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203200
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203200
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر