Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients
المؤلفون المشاركون
Ronco, Claudio
Corsi Romanelli, Massimiliano M.
de Cal, Massimo
Vianello, Elena
Ambrogi, Federico
Dozio, Elena
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
End-stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate due to cardiovascular diseases (CVD).
In these patients, inflammation, oxidative stress, and uremia increase the production of glycation products (AGEs) which in turn accelerate CVD onset and progression.
Recently, attention has been given to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis, and heart failure in CKD-G5D.
However, its association with patient outcomes is still under debate.
Our aim is to explore whether sRAGE may be a predictor of mortality in CKD-G5D.
We studied 123 CKD-G5D for 24 months.
Of these patients, 56 were on hemodialysis (HD) and 67 on peritoneal dialysis (PD).
Demographic, anthropometric, biochemical, and clinical data were recorded.
sRAGE was quantified by enzyme-linked immunosorbent assay.
sRAGE was a predictor of mortality at 2-year follow-up.
Each increase of 100 pg/mL in sRAGE levels was associated with an approximately 7% increased risk of mortality.
Furthermore, in the entire study group, as well as in PD and HD patient subgroups, sRAGE was positively correlated with brain natriuretic peptide (BNP) levels.
Mortality rates as well as sRAGE levels in patients who died did not differ between PD and HD patients.
In conclusion, the positive association observed with BNP levels suggests a role for sRAGE as a prognostic factor for mortality in CKD-G5D patients displaying an active process of cardiac remodeling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dozio, Elena& Ambrogi, Federico& de Cal, Massimo& Vianello, Elena& Ronco, Claudio& Corsi Romanelli, Massimiliano M.. 2018. Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203287
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dozio, Elena…[et al.]. Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203287
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dozio, Elena& Ambrogi, Federico& de Cal, Massimo& Vianello, Elena& Ronco, Claudio& Corsi Romanelli, Massimiliano M.. Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203287
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203287
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر