Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice
المؤلفون المشاركون
Burbano, Rommel Rodríguez
do Nascimento, José Luiz Martins
Hamoy, Moisés
de Góis Queiroz, Ana Isabelle
Maia, Cristiane Socorro Ferraz
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
Paraense, Ricardo Sousa de Oliveira
Macchi, Barbarella de Matos
Bittencourt, Leonardo Oliveira
Souza-Monteiro, José Rogério
Arrifano, Gabriela P. F.
Mello, Bruna S. F.
Custódio, Charllyany S.
Macêdo, Danielle S.
Rogez, Hervé
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half of those with the condition receive adequate treatment.
In addition, the high pharmacological refractoriness (affecting 30%-50% of patients) and toxicity of some classical antidepressants support the pursuit of new therapies.
People with this condition show depressed mood, loss of pleasure, high levels of oxidative stress, and accelerated biological aging (decreased telomere length and expression of the telomerase reverse transcriptase (TERT), the enzyme responsible for telomere maintenance).
Because of the close relationship between depression and oxidative stress, nutraceuticals with antioxidant properties are excellent candidates for therapy.
This study represents the first investigation of the possible antidepressant and antiaging effects of commercial samples of clarified açaí (Euterpe oleracea) juice (EO).
This fruit is rich in antioxidants and widely consumed.
In this study, mice were treated with saline or EO (10 μL/g, oral) for 4 days and then with saline or lipopolysaccharide (0.5 mg/kg, i.p.) to induce depressive-like behavior.
Only four doses of EO were enough to abolish the despair-like and anhedonia behaviors and alterations observed in electromyographic measurements.
The antidepression effect of EO was similar to that of imipramine and associated with antioxidant and antiaging effects (preventing lipid peroxidation and increasing TERT mRNA expression, respectively) in three major brain regions involved in depression (hippocampus, striatum, and prefrontal cortex).
Additionally, EO significantly protected hippocampal cells, preventing neuronal loss associated with the depressive-like state and nitrite level increases (an indirect marker of nitric oxide production).
Moreover, EO alone significantly increased TERT mRNA expression, revealing for the first time a potent antiaging action in the brain that suggests neuroprotection against long-term age-related consequences.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souza-Monteiro, José Rogério& Arrifano, Gabriela P. F.& de Góis Queiroz, Ana Isabelle& Mello, Bruna S. F.& Custódio, Charllyany S.& Macêdo, Danielle S.…[et al.]. 2019. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souza-Monteiro, José Rogério…[et al.]. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souza-Monteiro, José Rogério& Arrifano, Gabriela P. F.& de Góis Queiroz, Ana Isabelle& Mello, Bruna S. F.& Custódio, Charllyany S.& Macêdo, Danielle S.…[et al.]. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر