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Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence
المؤلفون المشاركون
Chin, Young-Won
Lee, Youngmun
Kim, Sunyoung
Oh, Yeonsoo
Kim, Young-Mi
Cho, Jungsook
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Among a series of xanthones identified from mangosteen, the fruit of Garcinia mangostana L.
(Guttifereae), α- and γ-mangostins are known to be major constituents exhibiting diverse biological activities.
However, the effects of γ-mangostin on oxidative neurotoxicity and impaired memory are yet to be elucidated.
In the present study, the protective effect of γ-mangostin on oxidative stress-induced neuronal cell death and its underlying action mechanism(s) were investigated and compared to that of α-mangostin using primary cultured rat cortical cells.
In addition, the effect of orally administered γ-mangostin on scopolamine-induced memory impairment was evaluated in mice.
We found that γ-mangostin exhibited prominent protection against H2O2- or xanthine/xanthine oxidase-induced oxidative neuronal death and inhibited reactive oxygen species (ROS) generation triggered by these oxidative insults.
In contrast, α-mangostin had no effects on the oxidative neuronal damage or associated ROS production.
We also found that γ-mangostin, not α-mangostin, significantly inhibited H2O2-induced DNA fragmentation and activation of caspases 3 and 9, demonstrating its antiapoptotic action.
In addition, only γ-mangostin was found to effectively inhibit lipid peroxidation and DPPH radical formation, while both mangostins inhibited β-secretase activity.
Furthermore, we observed that the oral administration of γ-mangostin at dosages of 10 and 30 mg/kg markedly improved scopolamine-induced memory impairment in mice.
Collectively, these results provide both in vitro and in vivo evidences for the neuroprotective and memory enhancing effects of γ-mangostin.
Multiple mechanisms underlying this neuroprotective action were suggested in this study.
Based on our findings, γ-mangostin could serve as a potentially preferable candidate over α-mangostin in combatting oxidative stress-associated neurodegenerative diseases including Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Youngmun& Kim, Sunyoung& Oh, Yeonsoo& Kim, Young-Mi& Chin, Young-Won& Cho, Jungsook. 2019. Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Youngmun…[et al.]. Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Youngmun& Kim, Sunyoung& Oh, Yeonsoo& Kim, Young-Mi& Chin, Young-Won& Cho, Jungsook. Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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