Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon
المؤلفون المشاركون
Sud’ina, Galina F.
Fedorova, Natalia V.
Ksenofontov, Alexander L.
Serebryakova, Marina V.
Stadnichuk, Vladimir I.
Gaponova, Tatjana V.
Galkina, Svetlana I.
Baratova, Ludmila
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In patients with reperfusion after ischemia and early development of diabetes, neutrophils can attach to blood vessel walls and release their aggressive bactericide agents, which damage the vascular walls.
Insulin and 17β-estradiol (E2) relieve the vascular complications observed in metabolic disorders.
In contrast, glucagon plays an essential role in the pathophysiology of diabetes.
We studied the effect of hormones on neutrophil secretion during adhesion to fibronectin.
Amino acid analysis revealed that proteins secreted by neutrophils are characterized by a stable amino acid profile enriched with glutamate, leucine, lysine, and arginine.
The total amount of secreted proteins defined as the sum of detected amino acids was increased in the presence of insulin and reduced in the presence of glucagon.
E2 did not affect the amount of protein secretion.
Proteome analysis showed that in the presence of insulin and E2, neutrophils secreted metalloproteinases MMP-9 and MMP-8 playing a key role in modulation of the extracellular matrix.
In contrast, glucagon induced the secretion of cathepsin G, a key bactericide protease of neutrophils.
Cathepsin G can promote the development of vascular complications because of its proinflammatory activity and ability to stimulate neutrophil adhesion via the proteolysis of surface receptors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fedorova, Natalia V.& Ksenofontov, Alexander L.& Serebryakova, Marina V.& Stadnichuk, Vladimir I.& Gaponova, Tatjana V.& Baratova, Ludmila…[et al.]. 2018. Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fedorova, Natalia V.…[et al.]. Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fedorova, Natalia V.& Ksenofontov, Alexander L.& Serebryakova, Marina V.& Stadnichuk, Vladimir I.& Gaponova, Tatjana V.& Baratova, Ludmila…[et al.]. Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر