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Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?
المؤلفون المشاركون
Lu, Yingli
Han, Bing
Li, Qin
Zhai, Hualing
Wang, Ningjian
Chen, Yi
Zhu, Chunfang
Chen, Yingchao
Zhao, Li
Chen, Chi
Zhang, Lijuan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The interrelation between thyroid autoimmunity and cardiovascular risks is complex and has not been confirmed.
This study aimed at evaluating whether there exists a relationship between thyroid autoimmune diseases (AITDs) and cardiometabolic risks in a large population with normal thyroid-stimulating hormone (TSH) levels.
Methods.
The data was obtained from a cross-sectional study (SPECT-China study).
This study enrolled 9082 subjects (3948 males and 5134 females) above 18 years with normal TSH levels.
AITD was defined according to the positivity of TPOAb and TgAb as well as thyroid ultrasonography (US) findings.
Results.
After full adjustment, TPOAb and/or TgAb positivity (TPO/TgAb (+)) was significantly associated with higher BMI, waist circumference (WC), and HbA1c only in women (P=0.004, 0.026 and 0.032, respectively), while both TPO/TgAb positivity and US positivity (TPO/TgAb (+) and US (+)) were positively associated with BMI and WC in both genders (P=0.002 and 0.020 in men; P<0.001and <0.001 in women).
TPO/TgAb (+) and US (+) were positively associated with HOMA-IR in women (P=0.021) as well.
Binary logistic analysis showed that AITDs had increased risks of central obesity, hyperlipidemia, and metabolic syndrome only in women (all P<0.05).
Moreover, TPO/TgAb (+) and US (+) were associated with an increased risk of obesity for both genders (P=0.014 in men and P=0.006 in women).
Conclusions.
Thyroid autoimmunity was positively associated with HbA1c, HOMA-IR, obesity, central obesity, hyperlipidemia, and metabolic syndrome, especially in women.
This highlighted that AITDs may be potential risk factors for cardiometabolic disorders even if one’s TSH was within the reference range.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yi& Zhu, Chunfang& Chen, Yingchao& Wang, Ningjian& Li, Qin& Han, Bing…[et al.]. 2018. Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yi…[et al.]. Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yi& Zhu, Chunfang& Chen, Yingchao& Wang, Ningjian& Li, Qin& Han, Bing…[et al.]. Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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