RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis
المؤلفون المشاركون
Shi, Fangxiong
Lv, Zengpeng
Jiang, Jingle
Ning, Chao
Dai, Hongjian
Jin, Song
Wei, Xihui
Yu, Debing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-25
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Little information has been available about the influence of dietary genistein (GEN) on hepatic transcriptome of laying broiler breeder (LBB) hens.
The study is aimed at broadening the understanding of RNA expression profiles and alternative splicing (AS) signatures of GEN-treated breeder hens and thereby improving laying performance and immune function of hens during the late egg-laying period.
720 LBB hens were randomly allocated into three groups with supplemental dietary GEN doses (0, 40 mg/kg, and 400 mg/kg).
Each treatment has 8 replicates of 30 birds.
Dietary GEN enhanced the antioxidative capability of livers, along with the increased activities of glutathione peroxidase and catalase.
Furthermore, it improved lipid metabolic status and apoptotic process in the liver of hens.
40 mg/kg dietary GEN had the better effects on improving immune function and laying performance.
However, transcriptome data indicated that 400 mg/kg dietary GEN did negative regulation of hormone biosynthetic process.
Also, it upregulated the expressions of EDA2R and CYR61 by the Cis regulation of neighbouring genes (lncRNA_XLOC_018890 and XLOC_024242), which might activate NF-κB and immune-related signaling pathway.
Furthermore, dietary GEN induced AS events in the liver, which also enriched into immune and metabolic process.
Therefore, the application of 40 mg/kg GEN in the diet of breeder hens during the late egg-laying period can improve lipid metabolism and immune function.
We need to pay attention to the side-effects of high-dose GEN on the immune function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Zengpeng& Jiang, Jingle& Ning, Chao& Dai, Hongjian& Jin, Song& Wei, Xihui…[et al.]. 2019. RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Zengpeng…[et al.]. RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1203415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Zengpeng& Jiang, Jingle& Ning, Chao& Dai, Hongjian& Jin, Song& Wei, Xihui…[et al.]. RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر