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Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease
المؤلفون المشاركون
Fuller, Kelly N. Z.
Miranda, Edwin R.
Thyfault, John P.
Haus, Jacob M.
Morris, J. K.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although there is evidence for metabolic dysfunction and chronic inflammation in Alzheimer’s disease (AD), circulating levels of soluble receptor for advanced glycation end products (sRAGE) and the receptor for advanced glycation end products (RAGE) ligand S100B have not been characterized.
sRAGE is an important mediator in disease as it can act as a ligand decoy for RAGE and attenuate downstream inflammatory signaling.
Cognitively healthy elderly and AD participants with and without type 2 diabetes (n=135) were stratified according to the clinical dementia rating (CDR; 0 = normal cognition (NC); ≥0.5 = AD).
Total serum sRAGE, endogenous secretory RAGE (esRAGE), and S100B were assayed via ELISAs, and cleaved RAGE (cRAGE) and the cRAGE : esRAGE ratio were calculated.
cRAGE : esRAGE was lower in AD compared to NC (p<0.05).
Metabolic substratifications were used to investigate the factors that influence sRAGE pathology in AD.
Stratification by BMI classification, median fat mass, median HOMA-IR, median insulin, and median amylin were all metabolic or anthropometric factors which significantly interacted with sRAGE profiles within AD subjects.
There were no significant differences in serum S100B between groups.
These characterizations of sRAGE contribute evidence to the link between impaired metabolism and cognitive decline due to AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fuller, Kelly N. Z.& Miranda, Edwin R.& Thyfault, John P.& Morris, J. K.& Haus, Jacob M.. 2018. Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fuller, Kelly N. Z.…[et al.]. Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fuller, Kelly N. Z.& Miranda, Edwin R.& Thyfault, John P.& Morris, J. K.& Haus, Jacob M.. Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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