Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial
المؤلفون المشاركون
Wu, Chun-Yu
Cheng, Ya-Jung
Lu, Yi-Fan
Wang, Man-Ling
Chen, Jin-Shing
Hsu, Yen-Chun
Yang, Fu-Sui
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
One-lung ventilation in thoracic surgery provokes profound systemic inflammatory responses and injury related to lung tidal volume changes.
We hypothesized that the highly selective a2-adrenergic agonist dexmedetomidine attenuates these injurious responses.
Sixty patients were randomly assigned to receive dexmedetomidine or saline during thoracoscopic surgery.
There is a trend of less postoperative medical complication including that no patients in the dexmedetomidine group developed postoperative medical complications, whereas four patients in the saline group did (0% versus 13.3%, p=0.1124).
Plasma inflammatory and injurious biomarkers between the baseline and after resumption of two-lung ventilation were particularly notable.
The plasma high-mobility group box 1 level decreased significantly from 51.7 (58.1) to 33.9 (45.0) ng.ml−1 (p<0.05) in the dexmedetomidine group, which was not observed in the saline group.
Plasma monocyte chemoattractant protein 1 [151.8 (115.1) to 235.2 (186.9) pg.ml−1, p<0.05] and neutrophil elastase [350.8 (154.5) to 421.9 (106.1) ng.ml−1, p<0.05] increased significantly only in the saline group.
In addition, plasma interleukin-6 was higher in the saline group than in the dexmedetomidine group at postoperative day 1 [118.8 (68.8) versus 78.5 (58.8) pg.ml−1, p=0.0271].
We conclude that dexmedetomidine attenuates one-lung ventilation-associated inflammatory and injurious responses by inhibiting alveolar neutrophil recruitment in thoracoscopic surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chun-Yu& Lu, Yi-Fan& Wang, Man-Ling& Chen, Jin-Shing& Hsu, Yen-Chun& Yang, Fu-Sui…[et al.]. 2018. Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chun-Yu…[et al.]. Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chun-Yu& Lu, Yi-Fan& Wang, Man-Ling& Chen, Jin-Shing& Hsu, Yen-Chun& Yang, Fu-Sui…[et al.]. Effects of Dexmedetomidine Infusion on Inflammatory Responses and Injury of Lung Tidal Volume Changes during One-Lung Ventilation in Thoracoscopic Surgery: A Randomized Controlled Trial. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر