Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction
المؤلفون المشاركون
Jadczyk, Tomasz
Zejda, Jan
Dołęgowska, Barbara
Marta, Niewczas
Syzdol, Marcin
Wanha, Wojciech
Kurzelowski, Radoslaw
Baranski, K.
Nabialek, E.
Ratajczak, M. Z.
Kucia, M.
Wojakowski, Wojciech
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation).
Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process.
Aim.
The aim of this study was to evaluate plasma levels of CC cleavage fragments (C3a, C5a, and C5b9), sphingosine (SP), sphingosine-1-phosphate (S1P), and free hemoglobin (fHb) in AMI patients treated with primary percutaneous coronary intervention (pPCI) and stable coronary artery disease (SCAD) undergoing CABG.
Patients and Methods.
The study enrolled 37 subjects (27 male) including 22 AMI patients, 7 CABG patients, and 8 healthy individuals as the control group (CTRL).
In the AMI group, blood samples were collected at 5 time points (admission to hospital, 6, 12, 24, and 48 hours post pPCI) and 4 time points in the CABG group (6, 12, 24, and 48 hours post operation).
SP and S1P concentrations were measured by high-performance liquid chromatography (HPLC).
Analysis of C3a, C5a, and C5b9 levels was carried out using high-sensitivity ELISA and free hemoglobin by spectrophotometry.
Results.
The plasma levels of CC cleavage fragments (C3a and C5b9) were significantly higher, while those of SP and S1P were lower in patients undergoing CABG surgery in comparison to the AMI group.
In both groups, levels of CC factors showed no significant changes within 48 hours of follow-up.
Conversely, SP and S1P levels gradually decreased throughout 48 hours in the AMI group but remained stable after CABG.
Moreover, the fHb concentration was significantly higher after 24 and 48 hours post pPCI compared to the corresponding postoperative time points.
Additionally, the fHb concentrations increased between 12 and 48 hours after PCI in patients with AMI.
Conclusions.
Inflammatory response after AMI and CABG differed regarding the release of sphingolipids, free hemoglobin, and complement cascade cleavage fragments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jadczyk, Tomasz& Baranski, K.& Syzdol, Marcin& Nabialek, E.& Wanha, Wojciech& Kurzelowski, Radoslaw…[et al.]. 2018. Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jadczyk, Tomasz…[et al.]. Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1203480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jadczyk, Tomasz& Baranski, K.& Syzdol, Marcin& Nabialek, E.& Wanha, Wojciech& Kurzelowski, Radoslaw…[et al.]. Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1203480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر