Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2ARE Defensive Pathway
المؤلفون المشاركون
Hseu, You Cheng
Yang, Hsin-Ling
Yen, Hung-Rong
Chang, Chih-Ting
Gowrisankar, Yugandhar Vudhya
Chen, Xuan-Zao
Lin, Hui-Chang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Ultraviolet A (UVA) irradiation (320-400 nm range) triggers deleterious consequences in skin cell microenvironment leading to skin damage, photoaging (premature skin aging), and cancer.
The accumulation of intracellular reactive oxygen species (ROS) plays a key role in this effect.
With rapid progress in cosmetic health and quality of life, use of safe and highly effective phytochemicals has become a need of the hour.
Zerumbone (ZER), a natural sesquiterpene, from Zingiber zerumbet rhizomes is well-known for its beneficial effects.
We investigated the antiphotoaging and dermatoprotective efficacies of ZER (2-8 μM) against UVA irradiation (3 J/cm2) and elucidated the underlying molecular mechanisms in human skin fibroblast (HSF) cells.
ZER treatment prior to low dose of UVA exposure increased cell viability.
UVA-induced ROS generation was remarkably suppressed by ZER with parallel inhibition of MMP-1 activation and collagen III degradation.
This was due to the inhibition of AP-1 (c-Fos and c-Jun) translocation.
Furthermore, ZER alleviated UVA-induced SA-β-galactosidase activity.
Dose- or time-dependent increase of antioxidant genes, HO-1 and γ-GCLC by ZER, was associated with increased expression and nuclear accumulation of Nrf2 as well as decreased cytosolic Keap-1 expressions.
Altered luciferase activity of ARE could explain the significance of Nrf2/ARE pathway underlying the dermatoprotective properties of ZER.
Pharmacological inhibition of various signaling pathways suppressed nuclear Nrf2 activation in HSF cells confirming that Nrf2 translocation was mediated by ERK, JNK, PI3K/AKT, PKC, AMPK, casein kinase II, and ROS signaling pathways.
Moreover, increased basal ROS levels and Nrf2 translocation seem crucial in ZER-mediated Nrf2/ARE signaling pathway.
This was also evidenced from Nrf2 knocked-out studies in which ZER was not able to suppress the UVA-induced ROS generation in the absence of Nrf2.
This study concluded that in the treatment of UVA-induced premature skin aging, ZER may consider as a desirable food supplement for skin protection and/or preparation of skin care products.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hseu, You Cheng& Chang, Chih-Ting& Gowrisankar, Yugandhar Vudhya& Chen, Xuan-Zao& Lin, Hui-Chang& Yen, Hung-Rong…[et al.]. 2019. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2ARE Defensive Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hseu, You Cheng…[et al.]. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2ARE Defensive Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hseu, You Cheng& Chang, Chih-Ting& Gowrisankar, Yugandhar Vudhya& Chen, Xuan-Zao& Lin, Hui-Chang& Yen, Hung-Rong…[et al.]. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2ARE Defensive Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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