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Notch1 Signaling Regulates the Th17Treg Immune Imbalance in Patients with Psoriasis Vulgaris
المؤلفون المشاركون
Xue, Haibo
Ma, Lei
Gao, Tianqin
Gao, MeiLan
Zhang, YuJie
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the regulating effect of Notch1 signaling on Th17/Treg immune imbalance in psoriasis vulgaris (PV).
Materials and Methods.
Notch1, Hes-1, RORγt, Foxp3, IL-17, and IL-10 mRNA expression, as well as Th17 and Treg cell percentages in peripheral CD4+ T cells, were detected by real-time quantitative RT-PCR and flow cytometry, and serum concentrations of IL-17 and IL-10 were detected by ELISA in 36 PV patients and 32 healthy controls.
Additionally, CD4+ T cells from 12 PV patients were treated with γ-secretase inhibitor DAPT, and the above indexes were measured.
Results.
PV patients presented distinct Th17/Treg immune imbalance and highly expressed Notch1 and Hes-1 mRNA levels, which were positively correlated with psoriasis area and severity index (PASI) and the ratios of Th17/Treg and RORγt/Foxp3.
DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORγt and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.
Conclusion.
Notch1 signaling may contribute to the pathogenesis of PV by regulating Th17/Treg immune imbalance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Lei& Xue, Haibo& Gao, Tianqin& Gao, MeiLan& Zhang, YuJie. 2018. Notch1 Signaling Regulates the Th17Treg Immune Imbalance in Patients with Psoriasis Vulgaris. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Lei…[et al.]. Notch1 Signaling Regulates the Th17Treg Immune Imbalance in Patients with Psoriasis Vulgaris. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Lei& Xue, Haibo& Gao, Tianqin& Gao, MeiLan& Zhang, YuJie. Notch1 Signaling Regulates the Th17Treg Immune Imbalance in Patients with Psoriasis Vulgaris. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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