Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan
المؤلفون المشاركون
Ouburg, Sander
Morré, Servaas A.
Roberts, Chrissy h.
Preston, Mark D.
de Vries, Henry J. C.
Holland, Martin J.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection and can lead to tubal factor infertility, a disease characterised by fibrosis of the fallopian tubes.
Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt/PI3K cascade, the mitotic cell cycle, and immune response have been identified in association with the development of trachomatous scarring, an ocular form of chlamydia-related fibrotic pathology.
In this case-control study, we performed genome-wide association and pathways-based analysis in a sample of 71 Dutch women who attended an STI clinic who were seropositive for Chlamydia trachomatis antibodies and 169 high-risk Dutch women who sought similar health services but who were seronegative.
We identified two regions of within-gene SNP association with Chlamydia trachomatis serological response and found that GPCR signalling and cell cycle pathways were also associated with the trait.
These pathway-level associations appear to be common to immunological sequelae of chlamydial infections in both ocular and urogenital tropisms.
These pathways may be central mediators of human refractoriness to chlamydial diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roberts, Chrissy h.& Ouburg, Sander& Preston, Mark D.& de Vries, Henry J. C.& Holland, Martin J.& Morré, Servaas A.. 2018. Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roberts, Chrissy h.…[et al.]. Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roberts, Chrissy h.& Ouburg, Sander& Preston, Mark D.& de Vries, Henry J. C.& Holland, Martin J.& Morré, Servaas A.. Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر