Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells
المؤلفون المشاركون
Lin, Yajun
Wang, Xiaoxia
Pan, Qi
Guo, Lixin
Zeng, Yi
Li, Dongxiao
Man, Fuli
Xiao, Fei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-19
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Much evidence demonstrates that mitochondrial dysfunction plays a crucial role in the pathogenesis of vascular complications of diabetes.
However, the signaling pathways through which hyperglycemia leads to mitochondrial dysfunction of endothelial cells are not fully understood.
Here, we treated human umbilical vein endothelial cells (HUVECs) with high glucose and examined the role of translocase of mitochondrial outer membrane (Tom) 22 on mitochondrial dynamics and cellular function.
Impaired Tom22 expression and protein expression of oxidative phosphorylation (OXPHOS) as well as decreased mitochondrial fusion were observed in HUVECs treated with high glucose.
The deletion of Tom22 resulted in reduced mitochondrial fusion and ATP production and increased apoptosis in HUVECs.
The overexpression of Tom22 restored the balance of mitochondrial dynamics and OXPHOS disrupted by high glucose.
Importantly, we found that Tom22 modulates mitochondrial dynamics and OXPHOS by interacting with mitofusin (Mfn) 1.
Taken together, our findings demonstrate for the first time that Tom22 is a novel regulator of both mitochondrial dynamics and bioenergetic function and contributes to cell survival following high-glucose exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Yi& Pan, Qi& Wang, Xiaoxia& Li, Dongxiao& Lin, Yajun& Man, Fuli…[et al.]. 2019. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1203587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Yi…[et al.]. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-23.
https://search.emarefa.net/detail/BIM-1203587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Yi& Pan, Qi& Wang, Xiaoxia& Li, Dongxiao& Lin, Yajun& Man, Fuli…[et al.]. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1203587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر