Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation
المؤلفون المشاركون
Yang, Yi
Ye, Qi-Fa
Liu, Zhongzhong
Zhong, Zibiao
Xia, Haoyang
Liang, Wenjin
Zeng, Xianpeng
Chen, Pu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-22
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI).
Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury.
We investigated whether the in vivo VNS can protect the liver from IRI.
In this study, hepatic IRI were induced by ligating the vessels supplying the left and middle lobes of the liver, which underwent 1 h occlusion followed with 24 h reperfusion.
VNS was initiated 15 min after ischemia and continued 30 min.
Hepatic function, histology, and apoptosis rates were evaluated after 24 h reperfusion.
Compared with the IRI group, VNS significantly improved hepatic function.
The protective effect was accompanied by a reduction in histological damage in the ischemic area, and the apoptosis rate of hepatocytes has considerable reduction.
To find the underlying mechanism, proteomic analysis was performed and differential expression of glutathione synthetase (GSS) and glutathione S-transferase (GST) was observed.
Subsequently, test results indicated that VNS upregulated the expression of mRNA and protein of GSS and GST.
Meanwhile, VNS increased the plasma levels of glutathione and glutathione peroxidases.
We found that VNS alleviated hepatic IRI by upregulating the antioxidant glutathione via the GSS/glutathione/GST signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xia, Haoyang& Liu, Zhongzhong& Liang, Wenjin& Zeng, Xianpeng& Yang, Yi& Chen, Pu…[et al.]. 2020. Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1203625
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xia, Haoyang…[et al.]. Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1203625
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xia, Haoyang& Liu, Zhongzhong& Liang, Wenjin& Zeng, Xianpeng& Yang, Yi& Chen, Pu…[et al.]. Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1203625
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203625
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر