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Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy
المؤلفون المشاركون
Ernberg, M.
Christidis, N.
Ghafouri, B.
Bileviciute-Ljungar, I.
Löfgren, M.
Bjersing, J.
Palstam, A.
Larsson, A.
Mannerkorpi, K.
Gerdle, B.
Kosek, E.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM.
Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women.
The FM women were then randomized to progressive resistance exercise (n=49) or relaxation (n=43).
Baseline IL-2, IL-6, TNF-α, IP-10, and eotaxin were higher in FM than in healthy controls (P<0.041), whereas IL-1β was lower (P<0.001).
There were weak correlations between cytokine levels and clinical variables.
After both interventions, IL-1ra had increased (P=0.004), while IL-1β had increased in the relaxation group (P=0.002).
Changes of IFN-γ, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables.
The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak.
However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables.
This trial is registered with ClinicalTrials.gov NCT01226784, registered October 21, 2010.
The first patient was recruited October 28, 2010.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ernberg, M.& Christidis, N.& Ghafouri, B.& Bileviciute-Ljungar, I.& Löfgren, M.& Bjersing, J.…[et al.]. 2018. Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1203632
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ernberg, M.…[et al.]. Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1203632
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ernberg, M.& Christidis, N.& Ghafouri, B.& Bileviciute-Ljungar, I.& Löfgren, M.& Bjersing, J.…[et al.]. Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1203632
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203632
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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