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Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis
المؤلفون المشاركون
Zwolinska, Danuta
Kopeć-Pyciarz, Karolina
Makulska, Irena
Łaczmański, Łukasz
Baran, Wojciech
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Psoriasis is currently regarded as a chronic systemic inflammatory disease associated with increased cardiovascular risk.
Advanced glycation end products (AGEs) contribute to the development of atherosclerosis.
Objectives.
The aim of the study was the assessment of skin autofluorescence (SAF), as a measure of AGE accumulation, in individuals suffering from chronic plaque psoriasis without any comorbid conditions.
Methods.
A study group consisted of 70 patients with chronic plaque psoriasis without any comorbid conditions and 59 healthy controls, matched by age and gender.
AGE accumulation was assessed by SAF (AGE Reader, DiagnOptics BV) which is a validated and noninvasive technique.
Relations between SAF and some clinical and laboratory data were assessed.
Results.
SAF was positively correlated with age both in patients with psoriasis and controls (R=0.722, p<0.00001 and R=0.613, p<0.00001, respectively).
There was significantly increased SAF in patients with psoriasis with elevated levels of C-reactive protein (CRP) and increased erythrocyte sedimentation rate (ESR) compared to controls (p<0.00001; p<0.00001, respectively, after adjustment to age).
Increased SAF was found in psoriatic patients with prediabetes (HbA1c 5.7–6.4%) compared to controls (p<0.0012, after adjustment to age).
Conclusion.
Systemic inflammation (increased CRP level), prediabetes, and aging may influence enhanced AGE accumulation in patients with psoriasis without any comorbidities.
SAF may be considered as a useful, noninvasive method to identify patients with psoriasis at increased cardiovascular risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kopeć-Pyciarz, Karolina& Makulska, Irena& Zwolinska, Danuta& Łaczmański, Łukasz& Baran, Wojciech. 2018. Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kopeć-Pyciarz, Karolina…[et al.]. Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis. Mediators of Inflammation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kopeć-Pyciarz, Karolina& Makulska, Irena& Zwolinska, Danuta& Łaczmański, Łukasz& Baran, Wojciech. Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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