Accelerated Kidney Aging in Diabetes Mellitus

المؤلفون المشاركون

Guo, Jing
Xia, Chen Hui
Han, Xue Ting
Huang, Wei Jun
Liu, Wei Jing
Wang, Yaoxian
Zheng, Hui Juan
Zhang, Wenting
Lou, Wenjiao
Zhang, Fan

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-24، 24ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-07-28

دولة النشر

مصر

عدد الصفحات

24

التخصصات الرئيسية

الأحياء

الملخص EN

With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance.

These aging-related alterations are more obvious and serious in diabetes mellitus (DM).

Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation.

The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype.

Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions.

Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers.

Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN).

However, their long-term benefits still need further study.

Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Guo, Jing& Zheng, Hui Juan& Zhang, Wenting& Lou, Wenjiao& Xia, Chen Hui& Han, Xue Ting…[et al.]. 2020. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1203640

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Guo, Jing…[et al.]. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-24.
https://search.emarefa.net/detail/BIM-1203640

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Guo, Jing& Zheng, Hui Juan& Zhang, Wenting& Lou, Wenjiao& Xia, Chen Hui& Han, Xue Ting…[et al.]. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1203640

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1203640