Accelerated Kidney Aging in Diabetes Mellitus
المؤلفون المشاركون
Guo, Jing
Xia, Chen Hui
Han, Xue Ting
Huang, Wei Jun
Liu, Wei Jing
Wang, Yaoxian
Zheng, Hui Juan
Zhang, Wenting
Lou, Wenjiao
Zhang, Fan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-28
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance.
These aging-related alterations are more obvious and serious in diabetes mellitus (DM).
Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation.
The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype.
Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions.
Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers.
Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN).
However, their long-term benefits still need further study.
Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Jing& Zheng, Hui Juan& Zhang, Wenting& Lou, Wenjiao& Xia, Chen Hui& Han, Xue Ting…[et al.]. 2020. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1203640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Jing…[et al.]. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-24.
https://search.emarefa.net/detail/BIM-1203640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Jing& Zheng, Hui Juan& Zhang, Wenting& Lou, Wenjiao& Xia, Chen Hui& Han, Xue Ting…[et al.]. Accelerated Kidney Aging in Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1203640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر