Reduced Liver Lipid Peroxidation in Subcellular Fractions Is Associated with a Hypometabolic State in Rats with Portacaval Anastomosis
المؤلفون المشاركون
Vázquez-Martínez, Olivia
Valente-Godínez, Héctor
Quintanar-Stephano, Andrés
Gasca-Martínez, Deisy
López-Cervantes, Mayra L.
Palma-Tirado, Lourdes
de Jesús Guerrero-Carrillo, María
Pérez-Solís, Mariela
Díaz-Muñoz, Mauricio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A surgical connection between portal and inferior cava veins was performed to generate an experimental model of high circulating ammonium and hepatic hypofunctioning.
After 13 weeks of portacaval anastomosis (PCA), hyperammonemia and shrinkage in the liver were observed.
Low glycemic levels accompanied by elevated levels of serum alanine aminotransferase were recorded.
However, the activity of serum aspartate aminotransferase was reduced, without change in circulating urea.
Histological and ultrastructural observations revealed ongoing vascularization and alterations in the hepatocyte nucleus (reduced diameter with indentations), fewer mitochondria, and numerous ribosomes in the endoplasmic reticulum.
High activity of hepatic caspase-3 suggested apoptosis.
PCA promoted a marked reduction in lipid peroxidation determined by TBARs in liver homogenate but specially in the mitochondrial and microsomal fractions.
The reduced lipoperoxidative activity was also detected in assays supplemented with Fe2+.
Only discreet changes were observed in conjugated dienes.
Fluorescent probes showed significant attenuation in mitochondrial membrane potential, reactive oxygen species (ROS), and calcium content.
Rats with PCA also showed reduced food intake and decreased energy expenditure through indirect calorimetry by measuring oxygen consumption with an open-flow respirometric system.
We conclude that experimental PCA promotes an angiogenic state in the liver to confront the altered blood flow by reducing the prooxidant reactions associated with lower metabolic rate, along with significant reduction of mitochondrial content, but without a clear hepatic dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vázquez-Martínez, Olivia& Valente-Godínez, Héctor& Quintanar-Stephano, Andrés& Gasca-Martínez, Deisy& López-Cervantes, Mayra L.& Palma-Tirado, Lourdes…[et al.]. 2019. Reduced Liver Lipid Peroxidation in Subcellular Fractions Is Associated with a Hypometabolic State in Rats with Portacaval Anastomosis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203641
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vázquez-Martínez, Olivia…[et al.]. Reduced Liver Lipid Peroxidation in Subcellular Fractions Is Associated with a Hypometabolic State in Rats with Portacaval Anastomosis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1203641
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vázquez-Martínez, Olivia& Valente-Godínez, Héctor& Quintanar-Stephano, Andrés& Gasca-Martínez, Deisy& López-Cervantes, Mayra L.& Palma-Tirado, Lourdes…[et al.]. Reduced Liver Lipid Peroxidation in Subcellular Fractions Is Associated with a Hypometabolic State in Rats with Portacaval Anastomosis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203641
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203641
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر