Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies

المؤلفون المشاركون

Mao, Zhi-Jie
Lin, Hui
Xiao, Fang-Yi
Huang, Zhou-Qing
Chen, Yi-He

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-06-27

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Aims.

Myocardial reperfusion damage after severe ischemia was an important issue during a clinical practice.

However, the exacted pathogenesis involved remained unclear and also lacks effective interventions.

Melatonin was identified to exert protective effects for alleviating the myocardial I/R injury.

This meta-analysis was determined to evaluate the efficacy of melatonin treatment against reperfusion insult and further summarize potential molecular and cellular mechanisms.

Methods and Results.

15 eligible studies with 211 animals (108 received melatonin and 103 received vehicle) were included after searching the databases of PubMed, MEDLINE, Embase, and Cochrane.

Pretreatment with melatonin was associated with a significant lower infarct size in comparison with vehicle in myocardial I/R damage (WMD: -20.45, 95% CI: -25.43 to -15.47, p<0.001; I2=91.4%, p<0.001).

Evidence from subgroup analyses and sensitivity analysis indicated the robust and consistent cardioprotective effect of melatonin, while the metaregression also did not unmask any significant interactions between the pooled estimates and covariates (i.e., sample size, state, species, study type, route of administration, and duration of reperfusion, along with timing regimen of pretreatment).

Accordingly, melatonin evidently increased EF (WMD: 17.19, 95% CI: 11.08 to 23.29, p<0.001; I2=77.0%, p<0.001) and FS (WMD: 14.18, 95% CI: 11.22 to 17.15, p<0.001; I2=3.5%, p=0.387) in the setting of reperfusion damage.

Conclusions.

Melatonin preadministration conferred a profound cardioprotection against myocardial I/R injury in preclinical studies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mao, Zhi-Jie& Lin, Hui& Xiao, Fang-Yi& Huang, Zhou-Qing& Chen, Yi-He. 2020. Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203642

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mao, Zhi-Jie…[et al.]. Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1203642

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mao, Zhi-Jie& Lin, Hui& Xiao, Fang-Yi& Huang, Zhou-Qing& Chen, Yi-He. Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203642

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1203642