Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
المؤلفون المشاركون
Yin, Yulong
Liu, Cui
Lv, Weijie
Chao, Limin
Guo, Shining
Yu, Lin-zeng
Zhou, Jia-hao
Li, Yue
Xiong, Ying
Guo, Ao
Qu, Qian
Wei, Guang-wei
Tang, Xing-gang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-31
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
There is a bidirectional relationship between inflammatory bowel disease (IBD) and depression/anxiety.
Emerging evidences indicate that the liver may be involved in microbiota-gut-brain axis.
This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury.
Long-term DSS-treatment increased lipopolysaccharide (LPS), proinflammation cytokines IL-1β and TNF-α, and gut leak in rats, breaking blood-brain barrier and overactivated astrocytes and microglia.
Ultimately, the rats showed depression-like behavior, including reduction of sucrose preference and central time in open field test and elevation of immobility time in a forced swimming test.
Oral administration with melatonin alleviated neuroinflammation and depression-like behaviors.
However, melatonin supplementation did not decrease the level of LPS but increase short-chain fatty acid (SCFA) production to protect DSS-induced neuroinflammation.
Additionally, western blotting analysis suggested that signaling pathways farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF 15) in gut and apoptosis signal-regulating kinase 1 (ASK1) in the liver overactivated in DSS-treated rats, indicating liver metabolic disorder.
Supplementation with melatonin markedly inhibited the activation of these two signaling pathways and its downstream p38.
As for the gut microbiota, we found that immune response- and SCFA production-related microbiota, like Lactobacillus and Clostridium significantly increased, while bile salt hydrolase activity-related microbiota, like Streptococcus and Enterococcus, significantly decreased after melatonin supplementation.
These altered microbiota were consistent with the alleviation of neuroinflammation and metabolic disorder.
Taken together, our findings suggest melatonin contributes to reshape gut microbiota and improves inflammatory processes in the hippocampus (HPC) and metabolic disorders in the liver of DSS rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Weijie& Liu, Cui& Yu, Lin-zeng& Zhou, Jia-hao& Li, Yue& Xiong, Ying…[et al.]. 2020. Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Weijie…[et al.]. Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1203644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Weijie& Liu, Cui& Yu, Lin-zeng& Zhou, Jia-hao& Li, Yue& Xiong, Ying…[et al.]. Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر