Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)‎

المؤلفون المشاركون

Li, Guang
Zhang, Xiaoning
Wang, Yuwen
Zhao, Rui
Hu, Xianyun
Zhang, Baoren
Lv, Xin
Guo, Zhenglong
Zhang, Zhiqiang
Yuan, Jinghua
Chu, Xu
Wang, Fei
Geng, Xin
Liu, Yang
Sui, Lei
Wang, Feng

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-12-17

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer’s disease, and cardiovascular disease.

However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined.

Accordingly, more effective treatment methods for sleep deficiency disorder are needed.

Thus, to better understand the detailed mechanism of sleep deficiency disorder, a sleep deprivation mouse model was established by the multiple platform method in our study.

The accumulation of free radicals and senescence-associated secretory phenotype (SASP) was observed in the sleep-deprived mice.

Moreover, our mouse and human population-based study both demonstrated that telomere shortening and the formation of telomere-specific DNA damage are dramatically increased in individuals suffering from sleeplessness.

To our surprise, the secretion of senescence-associated cytokines and telomere damage are greatly improved by folic acid supplementation in mice.

Individuals with high serum baseline folic acid levels have increased resistance to telomere shortening, which is induced by insomnia.

Thus, we conclude that folic acid supplementation could be used to effectively counteract sleep deprivation-induced telomere dysfunction and the associated aging phenotype, which may potentially improve the prognosis of sleeplessness disorder patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Xiaoning& Wang, Yuwen& Zhao, Rui& Hu, Xianyun& Zhang, Baoren& Lv, Xin…[et al.]. 2019. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203647

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Xiaoning…[et al.]. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203647

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Xiaoning& Wang, Yuwen& Zhao, Rui& Hu, Xianyun& Zhang, Baoren& Lv, Xin…[et al.]. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203647

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1203647