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Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study
المؤلفون المشاركون
Becerril, Enrique
Velasco-Velázquez, Marco Antonio
Arreola, Rodrigo
Cruz-Fuentes, Carlos
Alvarez-Herrera, Samantha
Pérez-Sánchez, Gilberto
Palacios, Lino
de la Peña, Francisco R.
Martínez-Levy, Gabriela
Hernández, María Eugenia
Pavon, Lenin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Changes in cytokine levels in major depression and during treatment have been reported in adults.
However, few studies have examined cytokine levels in an adolescent sample despite this being a common age of onset.
Methods.
We measured proinflammatory (IL-2, IFN-γ, IL-1β, TNF-α, IL-6, IL-12, and IL-15) and anti-inflammatory (IL-4, IL-5, IL-13, IL-1Ra, and IL-10) cytokine serum levels in 22 adolescents with major depression and 18 healthy volunteers.
Cytokines were measured by multiplex bead-based immunoassays at baseline, and 4 and 8 weeks after commencement of fluoxetine administration in the clinical group.
Results.
Compared to healthy volunteers, adolescents with major depression at baseline showed significant increases in all pro- and anti-inflammatory cytokines, except IL-1Ra and IL-10.
Significant changes were observed in fluoxetine treatment compared to baseline: proinflammatory cytokines IFN-γ, IL-1β, TNF-α, IL-6, IL-12, and IL-15 were decreased only at week 4 whereas IL-2 was increased only at week 8; anti-inflammatory cytokines IL-4 and IL-5 were increased at week 8 while IL-1Ra was reduced only at week 4.
There were no significant correlations between cytokine levels and symptomatic improvement in HDRS.
Discussion.
The results suggest a significant interplay between cytokine levels, the depressive state, and the stage of treatment with an SSRI.
To the best of our knowledge, this is the first report in depressed adolescents with elevated IL-12, IL-13, and IL-15 levels.
Further studies are necessary to clarify the role and mechanisms of altered cytokine levels in the pathogenesis and physiopathology of major depressive disorder.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pérez-Sánchez, Gilberto& Becerril, Enrique& Arreola, Rodrigo& Martínez-Levy, Gabriela& Hernández, María Eugenia& Velasco-Velázquez, Marco Antonio…[et al.]. 2018. Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pérez-Sánchez, Gilberto…[et al.]. Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pérez-Sánchez, Gilberto& Becerril, Enrique& Arreola, Rodrigo& Martínez-Levy, Gabriela& Hernández, María Eugenia& Velasco-Velázquez, Marco Antonio…[et al.]. Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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