Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
المؤلفون المشاركون
Santarelli, Lory
Bracci, Massimo
Malavolta, Marco
Giacconi, Robertina
Laura, Costarelli
Basso, Andrea
Sayeed, Md Abu
Pierpaoli, Elisa
Piacenza, Francesco
Provinciali, Mauro
Cardelli, Maurizio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-32، 32ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-12
دولة النشر
مصر
عدد الصفحات
32
التخصصات الرئيسية
الملخص EN
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer.
Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer.
Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers.
However, senolytic activity shown by some Nrf2-activating compounds could be used to target senescent cancer cells (particularly in aged immune-depressed organisms) that escape immunosurveillance.
We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.
In light of available literature, it can be concluded that the meaning and the potential of adjuvant therapy with natural compounds in humans remain unclear, also taking into account the existence of few clinical trials mostly characterized by uncertain results.
Further studies are needed to investigate the therapeutic potential of those compounds that display senolytic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malavolta, Marco& Bracci, Massimo& Santarelli, Lory& Sayeed, Md Abu& Pierpaoli, Elisa& Giacconi, Robertina…[et al.]. 2018. Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-32.
https://search.emarefa.net/detail/BIM-1203710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malavolta, Marco…[et al.]. Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation No. 2018 (2018), pp.1-32.
https://search.emarefa.net/detail/BIM-1203710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malavolta, Marco& Bracci, Massimo& Santarelli, Lory& Sayeed, Md Abu& Pierpaoli, Elisa& Giacconi, Robertina…[et al.]. Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-32.
https://search.emarefa.net/detail/BIM-1203710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر