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IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPKmTOR Pathway in Colorectal Cancer
المؤلفون المشاركون
Li, Yanzhang
Teng, Tie-Shan
Zhang, Lei
Wang, Qun
Liu, Fangyan
Liu, Wen
Song, Mengjiao
Yu, Qi
Tang, Kun
Wu, Dongdong
Wang, Xijing
Han, Wuqi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc–, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2).
Therefore, inducing ferroptosis through inhibiting the cystine/glutamate antiporter system xc– may be an effective way to treat cancer.
In previous screening tests, we found that the benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) significantly inhibited the viability of colorectal cancer cells.
However, the impact of IMCA on ferroptosis remains unknown.
Hence, this study investigated the effect of IMCA on ferroptosis and elucidated the underlying molecular mechanism.
Results showed that IMCA significantly inhibited the cell viability of colorectal cancer cells in vitro and inhibited tumor growth with negligible organ toxicity in vivo.
Further studies showed that IMCA significantly induced the ferroptosis of colorectal cancer cells.
Mechanistically, IMCA downregulated the expression of SLC7A11 and decreased the contents of cysteine and glutathione, which resulted in reactive oxygen species accumulation and ferroptosis.
Furthermore, overexpression of SLC7A11 significantly attenuated the ferroptosis caused by IMCA.
In addition, IMCA regulated the activity of the AMPK/mTOR/p70S6k signaling pathway, which is related to the activity of SLC7A11 and ferroptosis.
Collectively, our research provided experimental evidences on the activity and mechanism of ferroptosis induced by IMCA and revealed that IMCA might be a promising therapeutic drug for colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lei& Liu, Wen& Liu, Fangyan& Wang, Qun& Song, Mengjiao& Yu, Qi…[et al.]. 2020. IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPKmTOR Pathway in Colorectal Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203781
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lei…[et al.]. IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPKmTOR Pathway in Colorectal Cancer. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1203781
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lei& Liu, Wen& Liu, Fangyan& Wang, Qun& Song, Mengjiao& Yu, Qi…[et al.]. IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPKmTOR Pathway in Colorectal Cancer. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203781
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203781
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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