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Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils
المؤلفون المشاركون
Augustyniak, Daria
Roszkowiak, Justyna
Wiśniewska, Izabela
Skała, Jacek
Gorczyca, Daiva
Drulis-Kawa, Zuzanna
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-05
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP) play both pro- and anti-inflammatory activities and are produced during infection and inflammation.
Moraxella catarrhalis is one of the leading infectious agents responsible for inflammatory exacerbation in chronic obstructive pulmonary disease (COPD).
Since the airway inflammation in COPD is connected with activation of both epithelial cells and accumulated neutrophils, in this study we determined the in vitro effects of neuropeptides on the inflammatory potential of these cells in response to M.
catarrhalis outer membrane vesicle (OMV) stimulant.
The various OMV-mediated proinflammatory effects were demonstrated.
Next, using hBD-2-pGL4[luc2] plasmid with luciferase reporter gene, SP and CGRP were shown to inhibit the IL-1β-dependent expression of potent neutrophil chemoattractant, hBD-2 defensin, in transfected A549 epithelial cells (type II alveolar cells) upon OMV stimulation.
Both neuropeptides exerted antiapoptotic activity through rescuing a significant fraction of A549 cells from OMV-induced cell death and apoptosis.
Finally, CGRP caused an impairment of specific but not azurophilic granule exocytosis from neutrophils as shown by evaluation of gelatinase-associated lipocalin (NGAL) or CD66b expression and elastase release, respectively.
Concluding, these findings suggest that SP and CGRP mediate the dampening of proinflammatory action triggered by M.
catarrhalis OMVs towards cells engaged in lung inflammation in vitro.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Augustyniak, Daria& Roszkowiak, Justyna& Wiśniewska, Izabela& Skała, Jacek& Gorczyca, Daiva& Drulis-Kawa, Zuzanna. 2018. Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1203819
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Augustyniak, Daria…[et al.]. Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils. Mediators of Inflammation No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1203819
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Augustyniak, Daria& Roszkowiak, Justyna& Wiśniewska, Izabela& Skała, Jacek& Gorczyca, Daiva& Drulis-Kawa, Zuzanna. Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1203819
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203819
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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