Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation
المؤلفون المشاركون
Pinlaor, Somchai
Ma, Ning
Hiraku, Yusuke
Oikawa, Shinji
Ungarreevittaya, Piti
Midorikawa, Kaoru
Suwannakul, Nattawan
Thanan, Raynoo
Kawanishi, Shosuke
Murata, Mariko
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Various CD44 isoforms are expressed in several cancer stem cells during tumor progression and metastasis.
In particular, CD44 variant 9 (CD44v9) is highly expressed in chronic inflammation-induced cancer.
We investigated the expression of CD44v9 and assessed whether CD44v9 is a selective biomarker of human cholangiocarcinoma (CCA).
The expression profile of CD44v9 was evaluated in human liver fluke Opisthorchis viverrini-related CCA (OV-CCA) tissues, human CCA (independent of OV infection, non-OV-CCA) tissues, and normal liver tissues.
CD44v9 overexpression was detected by immunohistochemistry (IHC) in CCA tissues.
There was a higher level of CD44v9 expression and IHC score in OV-CCA tissues than in non-OV-CCA tissues, and there was no CD44v9 staining in the bile duct cells of normal liver tissues.
In addition, we observed significantly higher expression of inflammation-related markers, such as S100P and COX-2, in OV-CCA tissues compared to that in non-OV and normal liver tissues.
Thus, these findings suggest that CD44v9 may be a novel candidate CCA stem cell marker and may be related to inflammation-associated cancer development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suwannakul, Nattawan& Ma, Ning& Thanan, Raynoo& Pinlaor, Somchai& Ungarreevittaya, Piti& Midorikawa, Kaoru…[et al.]. 2018. Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suwannakul, Nattawan…[et al.]. Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suwannakul, Nattawan& Ma, Ning& Thanan, Raynoo& Pinlaor, Somchai& Ungarreevittaya, Piti& Midorikawa, Kaoru…[et al.]. Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر