Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients
المؤلفون المشاركون
Yin, Michael T.
Huang, Ying
Zhu, Biao
Yang, Zongxing
Xu, Yan
Xu, Lijun
Sun, Jia
Zheng, Jinlei
Kinloch, Sabine
Weng, Honglei
Wu, Nanping
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Butyrylcholinesterase (BChE) is synthesized mainly in the liver and an important marker in many infectious/inflammatory diseases, but its role in acquired immunodeficiency syndrome (AIDS) patients is not clear.
We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients.
Methods.
BChE levels (in U/L) were measured in 505 patients; <4500 was defined as “low” and ≥4500 as “normal.” Associations between BChE level and CD4 count, WHO stage, body mass index (BMI), C-reactive protein (CRP) level, and duration of hospitalization were assessed.
Kaplan–Meier curves and Cox proportional hazards model were used to assess associations between low BChE levels and mortality, after adjustment for age, CD4 count, WHO stage, and laboratory parameters.
Results.
A total of 129 patients (25.5%) had a lower BChE level.
BChE was closely associated with CD4 count, WHO stage, CRP level, and BMI (all P<0.001).
Eighty-four patients (16.6%) died in the first year of follow-up.
One-year survival was 64.5 ± 4.5% for patients with low BChE and 87.6 ± 1.8% for those with normal BChE (log-rank, P<0.001).
After adjustment for sex, age, BMI, WHO stage, and CD4 count, as well as serum levels of hemoglobin, sodium, and albumin, the hazard ratio was 1.8 (95% confidence interval, 1.0–3.2) for patients with a low BChE compared with those with a normal BChE (P=0.035).
Conclusion.
BChE level is associated with HIV/AIDS severity and is an independent risk factor for increased mortality in AIDS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lijun& Zhu, Biao& Huang, Ying& Yang, Zongxing& Sun, Jia& Xu, Yan…[et al.]. 2018. Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lijun…[et al.]. Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lijun& Zhu, Biao& Huang, Ying& Yang, Zongxing& Sun, Jia& Xu, Yan…[et al.]. Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر