Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression
المؤلفون المشاركون
Zhang, Huan-Ji
Wei, Ningle
Lu, Liuyi
Gao, Ming
Ghosh, Sounak
Liu, Zhaoyu
Qi, Junhua
Wang, Jingfeng
Chen, Jie
Huang, Hui
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Warfarin, a vitamin K antagonist (VKA), is known to promote arterial calcification (AC).
In the present study, we conducted a case-cohort study within the Multi-Ethnic Study of Atherosclerosis (MESA); 6655 participants were included.
From MESA data, we found that AC was related to both age and vitamin K; furthermore, the score of AC increased with SASP marker including interlukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) rising.
Next, a total of 79 warfarin users in our center developed significantly more calcified coronary plaques as compared to non-VKA users.
We investigated the role of warfarin in phosphate-induced AC in different ages by in vitro experimental study.
Furthermore, dose-time-response of warfarin was positively correlated with AC score distribution and plasma levels of the SASP maker IL-6 among patients<65 years, but not among patients≥65 years.
In addition, in vitro research suggested that warfarin treatment tended to deteriorate calcification in young VSMC at the early stage of calcification.
Our results suggested that aging and warfarin-treatment were independently related to increased AC.
Younger patients were more sensitive to warfarin-related AC than older patients, which was possibly due to accumulated warfarin-induced cellular senescence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Ningle& Lu, Liuyi& Zhang, Huan-Ji& Gao, Ming& Ghosh, Sounak& Liu, Zhaoyu…[et al.]. 2020. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Ningle…[et al.]. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Ningle& Lu, Liuyi& Zhang, Huan-Ji& Gao, Ming& Ghosh, Sounak& Liu, Zhaoyu…[et al.]. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر