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Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression
المؤلفون المشاركون
Zhang, Huan-Ji
Wei, Ningle
Lu, Liuyi
Gao, Ming
Ghosh, Sounak
Liu, Zhaoyu
Qi, Junhua
Wang, Jingfeng
Chen, Jie
Huang, Hui
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Warfarin, a vitamin K antagonist (VKA), is known to promote arterial calcification (AC).
In the present study, we conducted a case-cohort study within the Multi-Ethnic Study of Atherosclerosis (MESA); 6655 participants were included.
From MESA data, we found that AC was related to both age and vitamin K; furthermore, the score of AC increased with SASP marker including interlukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) rising.
Next, a total of 79 warfarin users in our center developed significantly more calcified coronary plaques as compared to non-VKA users.
We investigated the role of warfarin in phosphate-induced AC in different ages by in vitro experimental study.
Furthermore, dose-time-response of warfarin was positively correlated with AC score distribution and plasma levels of the SASP maker IL-6 among patients<65 years, but not among patients≥65 years.
In addition, in vitro research suggested that warfarin treatment tended to deteriorate calcification in young VSMC at the early stage of calcification.
Our results suggested that aging and warfarin-treatment were independently related to increased AC.
Younger patients were more sensitive to warfarin-related AC than older patients, which was possibly due to accumulated warfarin-induced cellular senescence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Ningle& Lu, Liuyi& Zhang, Huan-Ji& Gao, Ming& Ghosh, Sounak& Liu, Zhaoyu…[et al.]. 2020. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Ningle…[et al.]. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Ningle& Lu, Liuyi& Zhang, Huan-Ji& Gao, Ming& Ghosh, Sounak& Liu, Zhaoyu…[et al.]. Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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