Roles of Reactive Oxygen Species in Cardiac Differentiation, Reprogramming, and Regenerative Therapies
المؤلفون المشاركون
Liang, Jialiang
Wu, Min
Chen, Chen
Huang, Jing-Song
Zhu, Ping
Mai, Mingjie
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Reactive oxygen species (ROS) have been implicated in mechanisms of heart development and regenerative therapies such as the use of pluripotent stem cells.
The roles of ROS mediating cell fate are dependent on the intensity of stimuli, cellular context, and metabolic status.
ROS mainly act through several targets (such as kinases and transcription factors) and have diverse roles in different stages of cardiac differentiation, proliferation, and maturation.
Therefore, further detailed investigation and characterization of redox signaling will help the understanding of the molecular mechanisms of ROS during different cellular processes and enable the design of targeted strategies to foster cardiac regeneration and functional recovery.
In this review, we focus on the roles of ROS in cardiac differentiation as well as transdifferentiation (direct reprogramming).
The potential mechanisms are discussed in regard to ROS generation pathways and regulation of downstream targets.
Further methodological optimization is required for translational research in order to robustly enhance the generation efficiency of cardiac myocytes through metabolic modulations.
Additionally, we highlight the deleterious effect of the host’s ROS on graft (donor) cells in a paracrine manner during stem cell-based implantation.
This knowledge is important for the development of antioxidant strategies to enhance cell survival and engraftment of tissue engineering-based technologies.
Thus, proper timing and level of ROS generation after a myocardial injury need to be tailored to ensure the maximal efficacy of regenerative therapies and avoid undesired damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Jialiang& Wu, Min& Chen, Chen& Mai, Mingjie& Huang, Jing-Song& Zhu, Ping. 2020. Roles of Reactive Oxygen Species in Cardiac Differentiation, Reprogramming, and Regenerative Therapies. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203884
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Jialiang…[et al.]. Roles of Reactive Oxygen Species in Cardiac Differentiation, Reprogramming, and Regenerative Therapies. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1203884
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Jialiang& Wu, Min& Chen, Chen& Mai, Mingjie& Huang, Jing-Song& Zhu, Ping. Roles of Reactive Oxygen Species in Cardiac Differentiation, Reprogramming, and Regenerative Therapies. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203884
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203884
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر