Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties
المؤلفون المشاركون
Zhang, Lirong
Zhao, Qini
Yin, Liquan
Jiang, Dongli
Liu, Long
Ji, Hong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Myocarditis is one of the important causes of dilated cardiomyopathy, cardiac morbidity, and mortality worldwide.
Chitosan oligosaccharides (COS) may have anti-inflammatory and cardioprotective effects on myocarditis.
However, the exact molecular mechanism for the effects of functional COS on myocarditis remains unclear.
Methods.
Anti-inflammatory activities of COS (chitobiose, chitotriose, chitotetraose, chitopentaose, chitohexaose, chitoheptaose, and chitooctaose) were measured in lipopolysaccharide- (LPS-) stimulated RAW264.7 cells.
A rat model with myocarditis was established and treated with chitopentaose, chitohexaose, chitoheptaose, and chitooctaose.
Serum COS were measured by using high-performance liquid chromatography (HPLC) in all rats.
Myocarditis injury, the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS), inflammatory factors, and apoptotic factors were also measured.
Pearson’s correlation coefficient test was used to explore the relationship between the levels of ROS/RNS and cardiac parameters.
Results.
Among all chitosan oligosaccharides, the COS>degrees of polymerization DP 4 showed anti-inflammatory activities (the activity order was chitopentaose However, the serum level of chitooctaose was low whereas it showed significant therapeutic effects on myocarditis by improving cardiac parameters (left ventricular internal dimension, both end-systolic and end-diastolic, ejection fraction, and fractional shortening), inflammatory cytokines (IL-1β, IL-10, IL-17A, and IFN-γ), oxidative factors (ROS and RNS), and apoptotic factors (caspase 3, BAX, and BCL-2) when compared with chitopentaose, chitohexaose, and chitooctaose (COS DP>4). The levels of ROS/RNS had a strong relationship with cardiac parameters. Conclusions. Chitoheptaose plays a myriad of cardioprotective roles in the myocarditis model via its antioxidant, anti-inflammatory, and antiapoptotic activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Qini& Yin, Liquan& Zhang, Lirong& Jiang, Dongli& Liu, Long& Ji, Hong. 2020. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Qini…[et al.]. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Qini& Yin, Liquan& Zhang, Lirong& Jiang, Dongli& Liu, Long& Ji, Hong. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر