![](/images/graphics-bg.png)
The Emerging Role of Senescence in Ocular Disease
المؤلفون المشاركون
Kannan, Ram
Sreekumar, Parameswaran G.
Hinton, David R.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-09
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses.
An important role for senescence has been shown for a number of pathophysiological conditions that include cardiovascular disease, pulmonary fibrosis, and diseases of the skin.
However, whether senescence contributes to the progression of age-related macular degeneration (AMD) has not been studied in detail so far and the present review describes the recent research on this topic.
We present an overview of the types of senescence, pathways of senescence, senescence-associated secretory phenotype (SASP), the role of mitochondria, and their functional implications along with antisenescent therapies.
As a central mechanism, senescent cells can impact the surrounding tissue microenvironment via the secretion of a pool of bioactive molecules, termed the SASP.
An updated summary of a number of new members of the ever-growing SASP family is presented.
Further, we introduce the significance of mechanisms by which mitochondria may participate in the development of cellular senescence.
Emerging evidence shows that extracellular vesicles (EVs) are important mediators of the effects of senescent cells on their microenvironment.
Based on recent studies, there is reasonable evidence that senescence could be a modifiable factor, and hence, it may be possible to delay age-related diseases by modulating basic aging mechanisms using SASP inhibitors/senolytic drugs.
Thus, antisenescent therapies in aging and age-related diseases appear to have a promising potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sreekumar, Parameswaran G.& Hinton, David R.& Kannan, Ram. 2020. The Emerging Role of Senescence in Ocular Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sreekumar, Parameswaran G.…[et al.]. The Emerging Role of Senescence in Ocular Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1204004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sreekumar, Parameswaran G.& Hinton, David R.& Kannan, Ram. The Emerging Role of Senescence in Ocular Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)