PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury
المؤلفون المشاركون
Wang, Junlu
Mo, Yunchang
Lou, Yingying
Zhang, Anqi
Zhang, Jingjing
Zhu, Congying
Zheng, Bo
Li, Dan
Zhang, Mingyuan
Jin, Wenjun
Zhang, Lei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Sepsis is a systemic inflammatory reaction caused by infection.
Multiple organ failure ultimately leads to high morbidity and mortality.
Unfortunately, therapies against these responses have been unsuccessful due to the insufficient underlying pathophysiological evidence.
Protein interacting with C-kinase 1 (PICK1) has received considerable attention because of its important physiological functions in many tissues.
However, its role in sepsis-induced acute lung injury (ALI) is unclear.
In this study, we used cecal ligation and puncture (CLP) to establish a septic model and found that decreased microtubule-associated protein-1light chain 3 (LC3)-II/LC3-I in PICK1−/− septic mice was caused by autophagy dysfunction.
Consistently, the transmission electron microscopy (TEM) of bone marrow-derived macrophages (BMDMs) from PICK1−/− mice showed the accumulation of autophagosomes as well.
However, more serious damage was caused by PICK1 deficiency indicating that the disrupted autophagic flux was harmful to sepsis-induced ALI.
We also observed that it was the impaired lysosomal function that mediated autophagic flux blockade, and the autophagy progress was relevant to PI3K-Akt-mTOR pathway.
These findings will aid in the potential development of PICK1 with novel evidence of autophagy in sepsis treatment and prevention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mo, Yunchang& Lou, Yingying& Zhang, Anqi& Zhang, Jingjing& Zhu, Congying& Zheng, Bo…[et al.]. 2018. PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204059
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mo, Yunchang…[et al.]. PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204059
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mo, Yunchang& Lou, Yingying& Zhang, Anqi& Zhang, Jingjing& Zhu, Congying& Zheng, Bo…[et al.]. PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204059
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204059
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر