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Protection against UVB-Induced Photoaging by Nypa fruticans via Inhibition of MAPKAP-1MMP-1 Signaling
المؤلفون المشاركون
Lee, Sang-Han
Alam, Md Badrul
Choi, Hee-Jeong
Baek, Mi-Eun
Kwon, Yoon-Gyung
Lim, Ji-Young
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Ultraviolet B (UVB) irradiation is major causative factor in skin aging.
The aim of the present study was to investigate the protective effect of a 50% ethanol extract from Nypa fruticans (NF50E) against UVB-induced skin aging.
The results indicated that NF50E exerted potent antioxidant activity (IC50 = 17.55 ± 1.63 and 10.78 ± 0.63 μg/mL for DPPH and ABTS-radical scavenging activity, respectively) in a dose-dependent manner.
High-performance liquid chromatography revealed that pengxianencin A, protocatechuic acid, catechin, chlorogenic acid, epicatechin, and kaempferol were components of the extract.
In addition, the extract exhibited elastase inhibitory activity (IC50 = 17.96 ± 0.39 μg/mL).
NF50E protected against UVB-induced HaCaT cell death and strongly suppressed UVB-stimulated cellular reactive oxygen species generation without cellular toxicity.
Moreover, topical application of NF50E mitigated UVB-induced photoaging lesions including skin erythema and skin thickness in BALB/C mice.
NF50E treatment inhibited UVB-induced collagen degradation as well as MMP-1 and IL-1β expressions and significantly stimulated SIRT1 expression.
Furthermore, the extract treatment markedly suppressed the activation of NF-κB and AP-1 (p-c-Jun) by deactivating the p38 and JNK proteins.
Taken together, current data suggest that NF50E exhibits potent antioxidant potential and protection against photoaging by attenuating MMP-1 activity and collagen degradation possibly through the downregulation of MAPK/NF-κB/AP-1 signaling and SIRT1 activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Hee-Jeong& Alam, Md Badrul& Baek, Mi-Eun& Kwon, Yoon-Gyung& Lim, Ji-Young& Lee, Sang-Han. 2020. Protection against UVB-Induced Photoaging by Nypa fruticans via Inhibition of MAPKAP-1MMP-1 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Hee-Jeong…[et al.]. Protection against UVB-Induced Photoaging by Nypa fruticans via Inhibition of MAPKAP-1MMP-1 Signaling. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Hee-Jeong& Alam, Md Badrul& Baek, Mi-Eun& Kwon, Yoon-Gyung& Lim, Ji-Young& Lee, Sang-Han. Protection against UVB-Induced Photoaging by Nypa fruticans via Inhibition of MAPKAP-1MMP-1 Signaling. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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