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The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism
المؤلفون المشاركون
Zhang, Yaodong
Li, Chang Xian
Wang, Hong Wei
Jiang, Wang Jie
Li, Gao Chao
Luo, Chen Huan
Li, Xiang Cheng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism.
Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery.
Methods.
The association of AR expression with liver regeneration was studied in the rat small-for-size liver transplantation model and the mice major hepatectomy and hepatic IR injury model with or without fatty change.
The direct role and mechanism of AR in liver regeneration was explored in the AR knockout mouse model.
Results.
Delayed regeneration was detected in fatty liver after liver surgery in both rat and mouse models.
Furthermore, the expression of AR was increased in liver after liver surgery, especially in fatty liver.
In a functional study, the knockout of AR promoted liver regeneration at day 2 after major hepatectomy and IR injury.
Compared to wild-type groups, the expressions of cyclins were increased in normal and fatty livers of AR knockout mice.
AR inhibition increased the expressions of PPAR-α and PPAR-γ in both normal liver and fatty liver groups after major hepatectomy and IR injury.
In addition, the knockout of AR promoted the expressions of SDHB, AMPK, SIRT1, and PGC1-α in liver, which regulated mitochondrial biogenesis and energy metabolism.
Conclusions.
The knockout of AR promoted the regeneration of normal and fatty livers through regulating energy metabolism.
AR may be a new potential therapeutic target to accelerate liver regeneration after surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chang Xian& Wang, Hong Wei& Jiang, Wang Jie& Li, Gao Chao& Zhang, Yaodong& Luo, Chen Huan…[et al.]. 2020. The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204140
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chang Xian…[et al.]. The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204140
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chang Xian& Wang, Hong Wei& Jiang, Wang Jie& Li, Gao Chao& Zhang, Yaodong& Luo, Chen Huan…[et al.]. The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204140
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204140
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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