A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease
المؤلفون المشاركون
Durmanova, Vladimira
Parnicka, Zuzana
Javor, Juraj
Minarik, Gabriel
Vrazda, Lubomir
Vaseckova, Barbora
Gmitterova, Karin
Kralova, Maria
Pecenak, Jan
Filipcik, Peter
Shawkatova, Ivana
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most prevalent cause of dementia in elderly people worldwide.
Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression.
The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS.
Therefore, the objective of our study was to analyze the association between two polymorphisms located in the ITGA4 gene encoding the α4 subunit of VLA-4 and the risk of AD.
104 late-onset AD patients and 206 control subjects from Slovakia were genotyped for ITGA4 gene SNP polymorphism rs113276800 (−269C/A) and rs1143676 (+3061A/G).
The same study cohorts were also genotyped for the APOE-ε4, which is a known genetic factor associated with increased risk of AD developing.
ITGA4 polymorphism analysis revealed significantly higher frequency of the +3061AG carriers in AD group compared to the controls (P≤0.05).
Following the APOE-ε4 stratification of study groups, the association remained significant only in APOE-ε4 noncarriers.
Our study suggests a novel association of ITGA4 +3061A/G polymorphism with AD and its possible contribution to the disease pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Durmanova, Vladimira& Parnicka, Zuzana& Javor, Juraj& Minarik, Gabriel& Vrazda, Lubomir& Vaseckova, Barbora…[et al.]. 2018. A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Durmanova, Vladimira…[et al.]. A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1204190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Durmanova, Vladimira& Parnicka, Zuzana& Javor, Juraj& Minarik, Gabriel& Vrazda, Lubomir& Vaseckova, Barbora…[et al.]. A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر