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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients
المؤلفون المشاركون
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Kuźniewski, Marek
Drozdz, Ryszard
Żyłka, Agnieszka
Gala-Błądzińska, Agnieszka
Kucharz, Jakub
Ząbek-Adamska, Anna
Maziarz, Barbara
Dumnicka, Paulina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM).
Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression.
Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR).
Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2).
Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors.
Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration.
Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control.
In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year.
Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients.
Serum and urine NGAL correlated with eGFR changes.
Higher urine NGAL, KIM-1/creatinine ratio, and detectable IgG were significantly associated with the increase in uACR.
Widely available markers, serum cystatin C, urine IgG, transferrin, and NGAL, may help in early assessment of kidney disease in T2DM patients; however, large prospective studies are needed to confirm the conclusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Żyłka, Agnieszka& Dumnicka, Paulina& Kuśnierz-Cabala, Beata& Gala-Błądzińska, Agnieszka& Ceranowicz, Piotr& Kucharz, Jakub…[et al.]. 2018. Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204194
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Żyłka, Agnieszka…[et al.]. Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1204194
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Żyłka, Agnieszka& Dumnicka, Paulina& Kuśnierz-Cabala, Beata& Gala-Błądzińska, Agnieszka& Ceranowicz, Piotr& Kucharz, Jakub…[et al.]. Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204194
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204194
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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