A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH
المؤلفون المشاركون
Bobinger, T.
Bäuerle, T.
Seyler, L.
v Horsten, S.
Schwab, S.
Huttner, H. B.
Manaenko, A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Stroke activates the immune system and induces brain infiltration by immune cells, aggravating brain injury.
Poststroke immunomodulation via (S1P-)receptor modulation is beneficial; however, the S1P-modulator in clinical use (FTY-720) is unspecific, and undesirable side effects have been reported.
Previously, we tested effects of a novel selective S1P-receptor modulator, Siponimod, on ICH-induced brain injury in acute stage of the disease.
In the current study, we investigated whether protective effects of Siponimod, evaluated in a short-term study, will protect the brain of ICH animals at long term as well.
Methods.
134 C57BL/6N mice were divided into sham and ICH-operated groups.
Collagenase model of ICH was employed.
ICH animals were divided into Siponimod treated and nontreated.
Dose- and time-dependent effects of Siponimod were investigated.
Contraplay between development of brain injury and the number of lymphocytes infiltrating the brain was investigated by forelimb placing, T-Maze test, brain water content calculation, MRI scanning, and immunostaining.
Results.
Depending on the therapeutic strategy, Siponimod attenuated the development of brain edema, decreased ICH-induced ventriculomegaly and improved neurological functions of animals after ICH.
It was associated with less lymphocytes in the brain of ICH animals.
Conclusion.
Siponimod is able to decrease the brain injury and improves neurological functions of animals after ICH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bobinger, T.& Bäuerle, T.& Seyler, L.& v Horsten, S.& Schwab, S.& Huttner, H. B.…[et al.]. 2020. A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bobinger, T.…[et al.]. A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1204212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bobinger, T.& Bäuerle, T.& Seyler, L.& v Horsten, S.& Schwab, S.& Huttner, H. B.…[et al.]. A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر