A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1

المؤلفون المشاركون

Zhang, Shuping
Yin, Hui-Jun
Zhang, Lei
Zhang, Yan-Hong
Song, Ye-Wen
Li, Dan-Dan
Wang, Jing-Shang
Huang, Ye

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-04-10

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Hyperglycemia fluctuation is associated with diabetes mellitus (DM) complications when compared to persistent hyperglycemia.

Previous studies have shown that paeoniflorin (PF), through its antiapoptosis, anti-inflammation, and antithrombotic properties, effectively protects against cardiovascular and cerebrovascular disease.

However, the mechanism underlying the protection from PF against vascular injuries induced by hyperglycemia fluctuations remains poorly understood.

Herein, we investigated the potential protective role of PF on human umbilical vein endothelial cells (HUVECs) subjected to intermittent glucose levels in vitro and in DM rats with fluctuating hyperglycemia in vivo.

A remarkable increased apoptosis associated with elevated inflammation, increased oxidative stress, and high protein level of PKCβ1 was induced in HUVECs by intermittently changing glucose for 8 days, and PF recovered those detrimental changes.

LY333531, a potent PKCβ1 inhibitor, and metformin manifested similar effects.

Additionally, in DM rats with fluctuating hyperglycemia, PF protected against vascular damage as what has been observed in vitro.

Taken together, PF attenuates the vascular injury induced by fluctuant hyperglycemia through oxidative stress inhibition, inflammatory reaction reduction, and PKCβ1 protein level repression, suggesting its perspective clinical usage.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Jing-Shang& Huang, Ye& Zhang, Shuping& Yin, Hui-Jun& Zhang, Lei& Zhang, Yan-Hong…[et al.]. 2019. A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204218

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Jing-Shang…[et al.]. A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204218

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Jing-Shang& Huang, Ye& Zhang, Shuping& Yin, Hui-Jun& Zhang, Lei& Zhang, Yan-Hong…[et al.]. A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204218

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1204218