Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

الملخص EN

Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks.

Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β-cell dysfunction.

Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.