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Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2
المؤلفون المشاركون
Liu, Yuan
Zhao, Yintao
Sun, Jingjing
Zhang, Wei
Peng, Meng
Chen, Jun
Zheng, Lu
Zhang, Xiangqin
Yang, Haibo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Doxorubicin- (DOX-) induced cardiomyocyte loss results in irreversible heart failure, which limits the clinical applications of DOX.
Currently, there are no drugs that can effectively treat DOX-related cardiotoxicity.
Follistatin-like 1 (FSTL1) has been reported to be a transforming growth factor-beta-inducible gene, and FSTL1 supplementation attenuated ischemic injury and cardiac apoptotic loss in mice.
However, the effect of FSTL1 on DOX-induced cardiomyopathy has not been elucidated.
We aimed to explore whether FSTL1 could prevent DOX-related cardiotoxicity in mice.
Mice were intraperitoneally injected with a single dose of DOX to induce acute cardiotoxicity.
We used an adeno-associated virus system to overexpress FSTL1 in the heart.
DOX administration decreased FSTL1 mRNA and protein expression in the heart and in cells.
FSTL1 prevented DOX-related cardiac injury and inhibited cardiac oxidative stress and apoptosis, thereby improving cardiac function in mice.
FSTL1 also improved cardiomyocyte contractile functions in vitro.
FSTL1 upregulated expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in DOX-treated hearts.
FSTL1 was not capable of protecting against these toxic effects in Nrf2-deficient mice.
In conclusion, FSTL1 protected against DOX-induced cardiotoxicity via upregulation of Nrf2 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Yintao& Sun, Jingjing& Zhang, Wei& Peng, Meng& Chen, Jun& Zheng, Lu…[et al.]. 2020. Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Yintao…[et al.]. Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Yintao& Sun, Jingjing& Zhang, Wei& Peng, Meng& Chen, Jun& Zheng, Lu…[et al.]. Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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