Coccoloba alnifolia Leaf Extract as a Potential Antioxidant Molecule Using In Vitro and In Vivo Assays
المؤلفون المشاركون
Gomes, Dayanne Lopes
Cadavid, Cesar Orlando Muñoz
de Melo, Luciana Fentanes Moura
da Silva, Lucas Felipe
Silva, Larissa Marina Pereira
Machado, Marina Lopes
de Paula Oliveira, Riva
dos Santos, Deborah Yara Alves Cursino
Scortecci, Katia Castanho
Zucolotto, Silvana Maria
Rocha, Hugo Alexandre Oliveira
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The genus Coccoloba is widely used in traditional folk medicine, but few scientific data exist for this genus.
The goal of this study was to characterise the chemical composition and antioxidant activities of C.
alnifolia leaf extracts using in vitro and in vivo assays.
Six extracts were obtained: hexane (HE), chloroform (CE), ethanol (EE), methanol (ME), water end extract (WEE), and water extract (WE).
Thin-layer chromatography (TLC) analysis showed the presence of phenols, saponins, terpenes, and flavonoids.
In vitro assays demonstrated substantial antioxidant potential, especially for polar extracts (EE, ME, WEE, and WE).
Moreover, no toxic effects were observed on mammalian cell lines for most of the extracts at the concentrations evaluated.
The nematode Caenorhabditis elegans was also used as an in vivo model for testing antioxidant potential.
The EE and WE were chosen, based on previously obtained results.
It was observed that neither the EE nor the WE had any toxic effect on C.
elegans development.
Additionally, the antioxidant potential was evaluated using tert-butyl hydroperoxide as a stressor agent.
The EE increased the life span of C.
elegans by 28% compared to that of the control, and the WE increased the range to 39.2-41.3%.
High-performance liquid chromatography (HPLC-DAD) showed the presence of gallic acid, p-coumaric acid, and vitexin in the WE.
Therefore, in vitro and in vivo data demonstrated the antioxidant potential of C.
alnifolia extracts and their possible biotechnological applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Melo, Luciana Fentanes Moura& Gomes, Dayanne Lopes& da Silva, Lucas Felipe& Silva, Larissa Marina Pereira& Machado, Marina Lopes& Cadavid, Cesar Orlando Muñoz…[et al.]. 2020. Coccoloba alnifolia Leaf Extract as a Potential Antioxidant Molecule Using In Vitro and In Vivo Assays. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204392
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Melo, Luciana Fentanes Moura…[et al.]. Coccoloba alnifolia Leaf Extract as a Potential Antioxidant Molecule Using In Vitro and In Vivo Assays. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204392
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Melo, Luciana Fentanes Moura& Gomes, Dayanne Lopes& da Silva, Lucas Felipe& Silva, Larissa Marina Pereira& Machado, Marina Lopes& Cadavid, Cesar Orlando Muñoz…[et al.]. Coccoloba alnifolia Leaf Extract as a Potential Antioxidant Molecule Using In Vitro and In Vivo Assays. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204392
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204392
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر