Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes
المؤلفون المشاركون
Sun, Yu
Wang, Jun-Hui
Wang, Kexin
Song, Feng
Wang, Hongxing
Li, Hongyan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Neurons suffer detrimental effects from β-amyloid toxicity in Alzheimer’s disease.
The exercise hormone, irisin, is found to induce a neuroprotective gene program and facilitates the beneficial effects on cognitive function.
But no effort is made to test its direct protective effects on neurons against the Aβ-induced cell toxicity so far.
In the present study, we investigated whether irisin could protect neurons against Aβ- (25–35) induced cell damage and explored the possible underlying mechanisms.
Primary cell cultures of astrocytes and neurons were established.
Conditioned medium from astrocyte was collected for the treatment and biochemistry assay study.
To explore the protein expression changes, Western blot and ELISA assays were used in these in vitro cell culture models.
Exposure of hippocampal neurons to 10 μM Aβ (25–35) caused significant reduction on cell viability, and the toxic effect was not significantly reduced by the coadministration of irisin.
However, pretreated astrocyte-conditioned medium with irisin for 12 hours notably protected the neurons from the toxicity of Aβ.
Also, we found that irisin could attenuate the release of IL-6 and IL-1β from cultured astrocytes and decrease the expression level of COX-2 and phosphorylation of AKT.
Last, we found that irisin could reduce NFκB activation in astrocyte exposed to Aβ by preventing the phosphorylation and the loss of IκBα.
Our finding may provide novel evidence for the future application of irisin in the treatment of Alzheimer’s disease and the memory dysfunction in diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Kexin& Li, Hongyan& Wang, Hongxing& Wang, Jun-Hui& Song, Feng& Sun, Yu. 2018. Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1204398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Kexin…[et al.]. Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1204398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Kexin& Li, Hongyan& Wang, Hongxing& Wang, Jun-Hui& Song, Feng& Sun, Yu. Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1204398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر