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Decoding Aging: Understanding the Complex Relationship among Aging, Free Radicals, and GSH
المؤلفون المشاركون
Quintas-Granados, Laura Itzel
Trujillo-Ferrara, José Guadalupe
López-Navarro, María E.
Jarquín-Martínez, Mariana
Sánchez-Labastida, Luis A.
Ramírez-Rosales, Daniel
Godínez-Victoria, Marycarmen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
N-aryl maleimides can undergo a 1,4-Michael-type addition reaction with reduced glutathione (GSH), leading to a decreased concentration of GSH and an increased concentration of free radicals (FRs) in cells.
GSH is a critical scavenging molecule responsible for protecting cells from oxidation and for maintaining redox homeostasis.
N-aryl maleimides disturb redox homeostasis in cells because they scavenge thiol-containing molecules, especially GSH.
This study aimed at measuring the concentrations of GSH and FRs by electronic paramagnetic resonance (EPR), in the brain and liver tissue of male Wistar rats (ex vivo) at different ages and after treatment with 3,5-dimaleimylbenzoic acid (3,5-DMB).
Our results showed a relationship between age and the concentrations of GSH and FRs in cells.
In young rats, the concentration of GSH was higher than in old rats, while the concentration of FRs was higher in adult rats than in young rats, suggesting an inverse relationship between GSH and FRs.
On the other hand, the reaction of 3,5-DMB (an electrophilic maleimide) with cellular GSH increased the FR content.
The results of this study contribute to the awareness that the process of aging implies not only a loss of tissue function but also essential changes in the molecular contents of cells, especially the concentrations of FRs and GSH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López-Navarro, María E.& Jarquín-Martínez, Mariana& Sánchez-Labastida, Luis A.& Ramírez-Rosales, Daniel& Godínez-Victoria, Marycarmen& Quintas-Granados, Laura Itzel…[et al.]. 2020. Decoding Aging: Understanding the Complex Relationship among Aging, Free Radicals, and GSH. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204406
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López-Navarro, María E.…[et al.]. Decoding Aging: Understanding the Complex Relationship among Aging, Free Radicals, and GSH. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204406
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López-Navarro, María E.& Jarquín-Martínez, Mariana& Sánchez-Labastida, Luis A.& Ramírez-Rosales, Daniel& Godínez-Victoria, Marycarmen& Quintas-Granados, Laura Itzel…[et al.]. Decoding Aging: Understanding the Complex Relationship among Aging, Free Radicals, and GSH. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204406
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204406
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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