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Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis
المؤلفون المشاركون
Lee, Sung Ryul
Kang, Se Chan
Sohn, Eun-Hwa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Harmful, stressful conditions or events in the cardiovascular system result in cellular damage, inflammation, and fibrosis.
Currently, there is no targeted therapy for myocardial fibrosis, which is highly associated with a large number of cardiovascular diseases and can lead to fatal heart failure.
Hydrogen sulfide (H2S) is an endogenous gasotransmitter similar to nitric oxide and carbon monoxide.
H2S is involved in the suppression of oxidative stress, inflammation, and cellular death in the cardiovascular system.
The level of H2S in the body can be boosted by stimulating its synthesis or supplying it exogenously with a simple H2S donor with a rapid- or slow-releasing mode, an organosulfur compound, or a hybrid with known drugs (e.g., aspirin).
Hypertension, myocardial infarction, and inflammation are exaggerated when H2S is reduced.
In addition, the exogenous delivery of H2S mitigates myocardial fibrosis caused by various pathological conditions, such as a myocardial infarct, hypertension, diabetes, or excessive β-adrenergic stimulation, via its involvement in a variety of signaling pathways.
Numerous experimental findings suggest that H2S may work as a potential alternative for the management of myocardial fibrosis.
In this review, the antifibrosis role of H2S is briefly addressed in order to gain insight into the development of novel strategies for the treatment of myocardial fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Se Chan& Sohn, Eun-Hwa& Lee, Sung Ryul. 2020. Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Se Chan…[et al.]. Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Se Chan& Sohn, Eun-Hwa& Lee, Sung Ryul. Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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