Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury
المؤلفون المشاركون
Zhu, Qiqi
Chen, Xiaozhen
Wang, Yinglin
Xie, Xiang
Chen, Hongfei
Ge, Zhidong
Wei, Hua
Deng, Jingshong
Xia, Zhengyuan
Lian, Qingquan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress.
Heme oxygenase-1 (HO-1), an ER-anchored protein, exerts antioxidant and protective functions under ALI.
However, the role of HO-1 activation in the development of endoplasmic reticulum (ER) stress during sepsis remains unknown.
Methods.
Cecal ligation and puncture (CLP) model was created to induce septic ALI.
Lung tissue ER stress was measured 18 hours after CLP.
The effects of HO-1 on ER stress during septic ALI were investigated in vivo using HO-1 agonist hemin and antagonist ZnPP.
Results.
Compared with the sham group, ER stress in septic lung increased significantly 18 hours after CLP, which was significantly reduced by pretreatment with the ER inhibitor 4-phenylbutyrate (4-PBA).
The lung injury score and the lung wet to dry (W/D) ratio in lungs were significantly reduced in septic rats after ER stress inhibition.
Similarly, lung ER stress-related genes’ (PERK, eIF2-α, ATF4, and CHOP) levels were attenuated after ER stress inhibition.
Furthermore, HO-1 activation by hemin reduced p-PERK, p-eIF2-α, ATF4, and CHOP protein expression and oxidative stress and lung cell apoptosis.
Additionally, HO-1 antagonist could aggregate the ER stress-related ALI.
Conclusions.
ER stress was activated during CLP-induced ALI, which may represent a mechanism by which CLP induces ALI.
HO-1 activation could inhibit CLP-induced lung ER stress and attenuate CLP-induced ALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xiaozhen& Wang, Yinglin& Xie, Xiang& Chen, Hongfei& Zhu, Qiqi& Ge, Zhidong…[et al.]. 2018. Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xiaozhen…[et al.]. Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xiaozhen& Wang, Yinglin& Xie, Xiang& Chen, Hongfei& Zhu, Qiqi& Ge, Zhidong…[et al.]. Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر