HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
المؤلفون المشاركون
Yu, Hai-Fan
Duan, Cui-Cui
Yang, Zhan-Qing
Wang, Yu-Si
Yue, Zhan-Peng
Guo, Bin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
HB-EGF is essential for uterine decidualization, but its antioxidant function remains largely unclear.
Here, we found that HB-EGF promoted the proliferation of stromal cells followed by the accelerated transition of the cell cycle from G1 to S phase and enhanced the expression or activity of Prl8a2, Prl3c1, and ALP which were well-established markers for uterine stromal cell differentiation during decidualization.
Under oxidative stress, stromal cell differentiation was impaired, but this impairment was abrogated by rHB-EGF accompanied with the reduced levels of ROS and MDA which were regarded as the biomarkers for oxidative stress, indicating an antioxidant role of HB-EGF.
Further analysis revealed that HB-EGF enhanced the activities of antioxidant enzymes SOD, CAT, and GPX, where addition of GPX inhibitor MS attenuated the induction of rHB-EGF on Prl8a2, Prl3c1, and ALP.
Meanwhile, HB-EGF rescued the content of GSH and restored the ratio of GSH/GSSG after exposure to H2O2 but did not alter NOX activity.
Along with a decline for mitochondrial superoxide, exogenous rHB-EGF improved the damage of oxidative stress on mtDNA copy number, ATP level, mitochondrial membrane potential, and activities of mitochondrial respiratory chain complex I and III whose blockage by ROT and AA led to a failure of rHB-EGF in protecting stromal cell differentiation against injury.
Moreover, HB-EGF prevented stromal cell apoptosis by inhibiting Caspase-3 activity and Bax expression and recovering the level of Bcl-2 mRNA.
Collectively, HB-EGF might ameliorate oxidative stress-mediated uterine decidualization damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Hai-Fan& Duan, Cui-Cui& Yang, Zhan-Qing& Wang, Yu-Si& Yue, Zhan-Peng& Guo, Bin. 2019. HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Hai-Fan…[et al.]. HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1204474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Hai-Fan& Duan, Cui-Cui& Yang, Zhan-Qing& Wang, Yu-Si& Yue, Zhan-Peng& Guo, Bin. HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر